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Ask the literature. Get the trial, the paper and the page.

Human sleep research from the public biomedical infrastructure: the open-access full texts of PubMed Central articles under CC0, CC BY and CC BY-SA, ClinicalTrials.gov registrations, and one AHRQ evidence report from the NCBI Bookshelf, 77,899 texts, every one carrying its license and source. Research literature, not medical advice; no subscription literature, no abstracts of closed articles, no clinical practice guidelines.

docenta over MCP · the sleep collection
which trials tested melatonin for insomnia in older adults, what did they measure, and does the meta-analysis agree?
Answer

The registry and the papers answer together. NCT00230737, Melatonin Randomized Trial for Insomnia in the Elderly: phase 2, completed, 27 enrolled, 0.4 mg against 4.0 mg, for sleep initiation and maintenance disorders. NCT07695246: cognitive behavioural therapy for insomnia with and without adjunct melatonin in older adults, randomised, double-blind, placebo-controlled, measuring sleep, circadian outcomes and daytime functioning. The largest paper, Wade and colleagues, nightly prolonged-release melatonin for six months: 791 randomized, 722 analysed, patients 55 and older, sleep latency shortened by 15.6 minutes in the 65 to 80 group (95 percent CI minus 25.3 to minus 6.0). The systematic review and meta-analysis of melatonin and ramelteon in older adults with chronic insomnia searched 1990 to June 2021, the year the Beers Criteria chose, and pools these designs. One hit was dropped on reading: the tasimelteon phase III trial tests a receptor agonist, not melatonin.

Evidence
1.NCT00230737 · ClinicalTrials.gov registration · COMPLETED, PHASE2, enrollment 27 · Melatonin Randomized Trial for Insomnia in the Elderly: melatonin 0.4 mg, 4.0 mg
2.NCT07695246 · ClinicalTrials.gov registration · CBT-I with adjuvant melatonin in older adults with chronic insomnia, randomised, double-blind, placebo-controlled
3.Wade et al. · PMC open access · nightly prolonged release melatonin for 6 months · "the observed effect on sleep latency for patients aged 65-80 years (-15.6 min; 95% CI -25.3 to -6.0)"
4.Use of Melatonin and/or Ramelteon for the Treatment of Insomnia in Older Adults · systematic review and meta-analysis · PMC open access · "searches were conducted from 1 January 1990 to 20 June 2021"; Beers Criteria as the start
5.Synnott et al. · tasimelteon phase III · PMC open access · read and dropped: a melatonin receptor agonist, not melatonin
Conflict. None found in the retrieved evidence.
Gap. The primary outcome measure of NCT00230737 is on the registration, which this answer cited by title and arms; the endpoint line was not read. Whether the meta-analysis pooled Wade's trial is a question for its tables, one read away.
Evidence path · lexical lane over origin:sleep · 497 documents held every term · 2 registrations, 3 papers kept, 1 read and dropped

Real, from the sealed sleep collection, asked through the same engine the door serves, on 12 October 2026. Registrations and full texts on one answer, with the arms, the numbers and the one that did not belong.

The card, as the door says it

What is in the collection, and what is not.

Every door carries a card, sealed with the collection and shown to your assistant on every connection. This one reads:

Human sleep research from the public biomedical infrastructure: the open-access full texts of PubMed Central articles under CC0, CC BY and CC BY-SA, ClinicalTrials.gov registrations, and one AHRQ evidence report from the NCBI Bookshelf (a US Government work). Every text is openly licensed or in the public domain and carries its licence and source. It holds no subscription literature, no abstracts of closed articles and no clinical practice guidelines; it is research literature, not medical advice.

Sealed 2026-09-22; 77,899 texts; nothing is added, changed or removed, and a question outside the collection is answered "not in this corpus".

Full texts, openly licensed.

PubMed Central articles under CC0, CC BY and CC BY-SA, normalized with their license flags, cited to the passage.

Trial registrations.

ClinicalTrials.gov records with status, phase, enrollment, conditions and arms, so "which trial tested what" is answered from the registry and tied to the papers that report it.

What stays out.

Abstract-only records, author manuscripts and publisher open access under other licenses, the clinical practice guidelines, and the literature indexes that need the reader's own subscription.

Questions a plain search cannot answer cleanly

Ask across editions, across volumes, across the shelf.

Trials and papers

Which trials registered this intervention, with which arms, and which papers report them?

Which studies report this effect at this dose, and where do they disagree?

Which registration belongs to this paper?

Over time

What is the earliest paper here making this claim, and did a replication fail?

Which review pooled these trials, and what window did it search?

Evidence and gaps

Which papers cite the same underlying experiment rather than providing independent evidence?

What does the collection not contain on this question?

The collection, plugged into your assistant live door

One address, one sign-in, every answer cited to the passage.

The sealed collection above is served as an MCP server at https://sleep.docenta.ai/mcp: a public collection we host on purpose so your assistant can ask it today. You add it once; from then on it asks the collection the way it asked the question above, and reads the paper or the registration back with its license.

Register once

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https://sleep.docenta.ai/mcp

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claude mcp add --transport http docenta-sleep https://sleep.docenta.ai/mcp

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Ask, and read the citation

Every answer names the document and the page it came from. The first question after a quiet spell can take half a minute while the collection wakes up; your assistant is told so and asks again by itself.

The door never sees your files, and cannot be changed by anyone, us included, without a new seal and a new date on this page. It knows that a registered person asked, so each person gets a fair share of it. It keeps nothing you ask unless you choose to, with two boxes that start unticked when you connect: "tell me when a question can be answered later", which keeps only the questions the collection could not answer, and "keep my questions, without my name", which keeps the words for 180 days with no name, address or time of day beside them. You can change both on your start page.

What it will not pretend to know

Boundedness is the feature.

It is research literature, not medical advice. The door cites the paper, the page and the registration; what to do about it is not retrieval.

A near miss is read and dropped. A receptor agonist trial surfaced for a melatonin question; reading it put it out, and the answer says so.

The window is stated. A review's search dates are part of its citation, because a 2021 window cannot pool a 2026 trial.

The seal is the date. Nothing is added, changed or removed after the seal; a new seal means a new date on this page.

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